Director Technical

Dr. Shastri has served customers across the globe. Some noteworthy brands to his credit are US-Morton Grove Pharmaceuticals (wherein he served as a Resident Director) and Symbiotic, D & O Chemicals, Spectmore Import and Export associates, India-MOREPEN labs, Sterling Biotech, CIPLA, Matrix Laboratories, Cymbio Pharma, and many more. This speaks of his relentless endeavour with committed passion for excellence to serve customers with the best in analytical chemistry and biosciences.

Dr. Shastri could accomplish serving many Pharma companies and chemical laboratories, only for his one unique decision to serve as a consultant for reputed firms and use his expertise for the benefit of the companies and masses at large. You can know more about his recent accomplishment from the modest man himself, and this I believe isn’t the right place to enlist all the accolades in his career span. Currently, Dr. Shastri chairs as the Director-Technical for Murli Krishna Pharma Private Limited since its inception in 2004. He has been responsible for designing and commissioning of the MKPPL project, right from scratch. At MKPPL, Dr. Shastri is responsible for the development of semi-finished formulations based on Proton pump inhibitors, anti-fungal drugs, immune suppressants, Macrolide, anti-obesity products, conducting bio equivalence studies and Liasoning with API manufacturers to develop APIs with the right polymorphic character as well as impurity profile.

Honing expertise into the area of analytical chemistry, Dr. Shastri has been conducting seminars and workshops in the field of chromatography and spectroscopy with noted academic institutions and industries across the length and breadth of the country.

1) Director Technical – Murli Krishna Pharma Pvt. Ltd. – April 2004 till Date

Designing and Commissioning of the MKPPL Project from Nascent Stage.

Responsibilities :

Development of semi-finished formulations based on Proton pump inhibitors, anti-fungal drugs, immune suppressants, Macrolide, anti-obesity products. Semi-finished formulations are based on time release profile. Responsible for analytical method development and validations. Setting up of stability programme. Coordination for conducting bio equivalence studies. Liasoning with API manufacturers to develop API with the right polymorphic character as well as impurity profile.

2) Period : March 1993-March 2008

Worked as a consultant. Provided consultancy services to organisations in India as well as abroad.

Provided consultancy services in the field of:

• Trouble shooting in synthesis of API’s, formulations.
• Developing downstream processing procedures for isolation of active principles from Fermentation broth.
• Impurity and polymorph characterisation using NMR, Mass Spectrometry, LC-MS-MS
• Liasoning with CRO’s for developing protocols for conducting bio-equivalence studies, coordinating with CRO’s for conducting bio equivalence studies.
• Setting up of projects for API’s (based on synthesis as well fermentation), formulations, and analytical labs.
• Standardising procedures for the extraction of active principles from plant products.
• Development of analytical techniques for monitoring API synthesis, formulation, stability studies, bio-analysis.

Key Customers

• US-Morton Grove Pharmaceuticals (Resident Director), Symbiotic, D & O Chemicals, Spectmore Import and Export associates, Collymore and Company.
• Italy-Biofin Labs
• China
• Singapore-Fe-Century, Sloan Impex, Zagroasia
• Hong Kong-Royal Hong Kong Jockey Club
• Germany
• Vietnam
• Hong Kong-Unico and Company
• Bangladesh
• Cyprus

India-MOREPEN labs (was a part of the team that developed Atorvastatin Polymorph, Fluvastatin Polymorph, Loratadine, Fexofenadine, Pioglitazone and Montelukast), Sterling Biotech (provided consultancy services when setting up their biotech project at Masar, Vadodara as well as their formulation unit in Pune), CIPLA, Matrix Laboratories, Cymbio Pharma, Therapeutic Drug Monitoring Laboratory.

3) Period : 1988-2003

Worked as a Deputy General Manager-Analytical Research for Merind (Merck Sharpe and Dohme).

• Was responsible for evaluating development in the field of synthesis, fermentation, formulations and natural products.
• Set up a modern downstream processing system for isolation of Vitamin B12.
• Responsible for standardising Grignard’ reaction for three products.
• Cost reduction in Dexamethasone and Betamethasone synthesis.
• Coordinating with CRO’s for conducting bio equivalence.

4) Period : 1986-1988

Worked with Lupin /Armour Chemicals as a Quality Assurance and Analytical Development Manager.

• Set up analytical procedures for monitoring the synthesis of Beta Lactums, Cephalosporin’s, and intermediates like 6-APA, 7-ACA, and 7-ADCA though fermentation.

5) Period : 1984-1986

Worked as a Chemist with Abbott Laboratories.

• Developed procedures to monitor synthesis of Nembutal Ester, Sodium Pentothal and Erythromycin derivatives. The procedures enabled in improving the yield as well as impurity profile as the procedures through light on the impurities and by products which enabled in improving the process operations.

6) Period : 1981-1983

Worked as an applications Chemist with Nettle Chromatographs.

• Developed chromatographic procedures (GC as well as HPLC) for supporting the sale of chromatographic equipment. The applications were oriented towards pharmaceutical industry, based on both API as well as formulations.

Academic Qualifications :

1983-1986 : Obtained PhD from University of Mumbai. Subject : Analytical Chemistry. Title of the Thesis: – Development of analytical procedures for evaluation of drugs from pharmaceutical preparations and extend the same for conducting bioequivalence.

1979-1981 : Obtained Master’s Degree in the field of Analytical Chemistry

1975-1979 : Obtained Bachelor’s Degree with Chemistry as the Principal Subject and Physics as the subsidiary subject.

1964-1975 : Passed Secondary School Certificate Exam from Indian Education Society’s English Medium School, Dadar, Mumbai.

Other Achievements : Have conducted seminars in the field of Chromatography and Spectroscopy with noted academic institutions as well as industries.