Pellets

Aprepitant Pellets 40.0% – Ready to Fill Into Capsules (Dose: 40 mg, 80 mg, or 125 mg)

• Matches with the innovator product in terms of the dissolution profile
• Conducted and cleared multimedia dissolution studies against the innovator product
• Offers a non-infringing product
• Do offer development services in case of a requirement for different formulation/dosage/strength
• Offer complete technical package for registrations in all regulated/semi regulated markets

Dexlansoprazole DDR Pellets 17%, 20%, 22.5%, 23% – Suitable for Capsules (Dose: 30 mg, 60 mg)

The pharmaceutical form of dexlansoprazole is based on the unique technology of modified dual release. The active ingredient is released in two phases at different pH values and with a time interval. Consequently, the drug achieves two peak concentrations in the blood, and the total serum concentration of dexlansoprazole is three times higher.

• MKPPL has developed Dexlansoprazole pellets by aqueous technology to match the dissolution profile of Dexlansoprazole Pellets with Innovator.
• The product developed is comparable with innovator with respect to dissolution profile of the marketed product.
• We offer development services if different formulations/dosages/strengths are required
• Offer complete technical package for registrations in all regulated/semi regulated markets
• Products protected by ongoing Patents are not offered by MKPPL.

Esomeprazole EC Pellets / MUPS / Granules 8.5%, 22.5% – Suitable for Capsules, Tablets (dose: 20 mg, 40 mg)

• Esomeprazole is the chiral form of omeprazole. The product is manufactured as enteric coated pellets by aqueous technology to match with Innovator without use of organic solvent.
• The product developed is comparable with innovator with respect to dissolution profile of the marketed product.
• The quality of the pellets is based on the in-vitro dissolution test besides the assay and the impurity profile. The time dissolution values are direct measures of the coating efficiency and hence optimum therapeutic efficacy as it has a co-relation with in-vivo behaviors.
• We do offer development services in case of a requirement for different formulation/dosage/strength
• Offer complete technical package for registrations in all regulated/semi regulated markets
• Products protected by ongoing Patents are not offered by MKPPL.

Esomeprazole is also proton pump inhibitor and is one of the blockbuster molecule that is used in the treatment of ulcer.

Lansoprazole EC Pellets Suitable for filling in 15mg & 30mg Capsules, MUPS, Premix (sachet) & 30mg Tablets.

Lansoprazole is a second-generation proton pump inhibitor and is one of the blockbuster molecule that is used in the treatment of ulcers.

• Release pattern compared with innovator -Prevacid delayed-release capsules and Prevacid solutab delayed-release orally disintegrating tablets.
• A comparative dissolution was conducted for Lansoprazole capsules of Murli Krishna Pharma and prevacid capsules which compare favorably.
• The focal intent of the MKPPL was to develop a stable; pharmaceutically equivalent, robust and delayed release micro pellet formulation of Lansoprazole for both capsule and orally disintegrating tablets.
• Offer complete technical package for registrations in all regulated/semi regulated markets.

Mesalamine SR Pellets / Granules 

Mesalamine is a drug used for treating ulcerative colitis. Although the exact mechanism of mesalamine is not known it is believed to be reducing the inflammation in the colon through systemic action.

• Mesalamine is an anti-inflammatory agent used to treat ulcerative colitis. Mesalamine comes as a Delayed-release tablet, Delayed-release capsule, Controlled-release capsule, Extended-release capsule, Suppositories.
• Mesalamine ER Pellets have dissolution time of 8 hours and are released as per the USP Monograph.
• We do offer development services in case of a requirement for different formulation/dosage/strength
• Offer complete technical package for registrations in all regulated/semi regulated markets
• Products protected by ongoing Patents are not offered by MKPPL.

Omeprazole Pellets 8.5%, 10%, 20%, 22%, 22.5%, 30% – Suitable for Capsules (Dose: 10 mg, 20 mg, 40 mg)

Omeprazole is a widely used proton pump inhibitor that is used in the treatment of peptic ulcers.

• Omeprazole delayed-release oral suspension is a proton pump inhibitor (PPI). It works by decreasing the amount of acid produced in the stomach.
• The product developed is comparable with innovator with respect to dissolution profile of the marketed product.
• We offer complete technical package for registrations in all regulated/semi regulated markets
• The DMF file for Omeprazole Pellets 8.5% is submitted to the USFDA and is awaiting review.
  The EDMF file for Omeprazole Pellets 8.5% is submitted with the National Authorities is Greece and Romania and is awaiting review.
• Omeprazole Pellets 8.5% BA/BE Studies have been successfully completed by the end users.
• Products protected by ongoing Patents are not offered by MKPPL.

Pantoprazole is used to treat gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and injury of the food pipe (esophagus). It is also used to treat conditions where the stomach produces too much acid, such as Zollinger-Ellison syndrome.